Document Type : Research Paper

Authors

• Hamidreza Yahyaeipour ¹
• farzaneh ganji ²
• zahra nazari ¹
• hamid sepehri ³

¹ Department of Biology, School of Sciences, Golestan University, Gorgan, Iran.

² Department of Biology, School of Sciences, Golestan University, Gorgan, Iran

³ Department of Physiology, Neuroscience Research Center, Golestan University of Medical Science, Gorgan, Iran.

Abstract

Quercetin is a flavonoid with anti-inflammatory properties. Considering the effect of diabetes. Since diabetes leads to olfactory dysfunctions, this research was conducted with the aim of the effect of quercetin on the histomorphometric changes of the olfactory bulb caused by diabetes in male Wistar rats. In this experimental study, 24 male Wistar rats were used in this research. Animals were randomly divided into three groups (control group, diabetic group, and quercetin-treated diabetic group). In the second and third groups, diabetes was induced by intraperitoneally injecting 20 mg/kg of streptozotocin for five consecutive days. Rats in the third group were treated with oral administration of 100 mg/kg of quercetin for 35 days. Finally, the olfactory bulbs of all groups were isolated for histomorphometric analysis of the olfactory bulbs. The thickness of the olfactory bulb in the diabetic group decreased compared to the control group. In the quercetin-treated group, an increase in the thickness of the olfactory bulb layers was observed. The number of glomeruli and also the thickness of the inner plexiform layer in the quercetin group significantly increased compared to untreated diabetic rats (p< 0.05). The present study indicated that quercetin can modulate the olfactory bulb morphologic changes caused by hyperglycemia. Therefore, quercetin can be used as a food supplement to treat olfactory disorders in diabetic patients.

Keywords

• Diabetes mellitus
• Flavonoids
• Olfactory disfunction
• Streptozotocin

Main Subjects

• Physiology