Document Type : Research Paper

Authors

• Tahereh Naji ¹
• Mahzad Biniaz ²
• saeed mohamadi motamed ³
• Yasaman Sheybani ⁴

¹ Associate professor, Department of Basic Science, Faculty of pharmacy and pharmaceutical sciences, Tehran medical sciences, Islamic azad university, Tehran, Iran

² Student of pharmacy, Department of Basic Science, Faculty of pharmacy and pharmaceutical sciences, Tehran medical sciences, Islamic azad university, Tehran, Iran.

³ Assistant professor, Department of Pharmacognosy, Faculty of pharmacy and pharmaceutical sciences, Tehran medical sciences, Islamic azad university, Tehran, Iran.

⁴ Department of Basic Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Abstract

Haloperidol is a dopamine receptor antagonist and is used in the treatment of mental illnesses. Morus alba is a plant belonging to the Moracea family. Morus alba leaves have antidopaminergic effects like haloperidol. The purpose of this research is to compare the effect of Morus alba leaves extract and haloperidol as two antidopaminergic substances on the level of hepatic enzymes and liver tissue in adult female three spot gourami fish. For this purpose, the number of 120 pieces of fish in 8 groups including intact control group, solvent control, treatments receiving doses of 0.05, 0.1 and 0.2 mg/kg of haloperidol, and doses of 50, 100 and 200 mg/kg of ethanol extract of Morus alba leaves, they were divided. Medicines were administered intramuscularly every other day for a period of twenty days. After finishing the injections, liver enzymes and liver tissue were studied in all groups. The statistical results showed that There was a significant difference between the level of liver enzymes in the control and treated groups (P < 0.05) in such a way that by increasing the dose, haloperidol increased liver enzymes and damage to liver cells, while the extract of Morus alba leaves, led to the reduction of liver enzymes and protection of liver cells. Therefore, haloperidol can cause hepatotoxicity, but Morus alba extract is probably hepatoprotective.

Keywords

• Halperidol
• Morus alba
• iver
• Trichogaster trichopterus

Main Subjects

• Histology