Phlorotannins, a group of polyphenol compounds found in brown seaweed, possess various beneficial properties such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancer, and neuroprotective effects. These biological activities have led to an increased demand worldwide. In this research, brown algae sourced from the Persian Gulf were utilized to extract phlorotannins. Subsequently, mesenchymal stem cells and neutrophils from NMRI mice were isolated, cultured in specific media, and exposed to varying concentrations of phlorotannin (0, 20, 60, and 100 mg/ml). The findings revealed that the survival of these cells remains unaffected with increasing compound concentrations. However, there was an enhancement in the survival and proliferation of mesenchymal stem cells. Moreover, the concentration-dependent decrease in the activity of the inflammatory enzyme nitric oxide (NO) and the secretion of the proinflammatory cytokine IL-1β were observed. Conversely, an increase in the respiratory burst of neutrophils and the secretion of immunomodulatory cytokines such as IL-10 and TGF-β was noted with higher phlorotannin concentrations. These results underscore the potent anti-inflammatory effects of these compounds, deemed safe for use due to their lack of cytotoxicity, offering a promising alternative to conventional chemicals and drugs.
Mahmoudzadeh,L. , Abtahi Froushani,S. . M. , Mahmoudzadeh,M. and Aliyari,A. (2025). The effect of phlorotannin in brown algae on the function of mesenchymal stem cells and neutrophils of NMRI mice. Journal of Animal Research
(Iranian Journal of Biology), 38(3), 199-215. doi: 10.22034/cmr.2025.8480.3302
MLA
Mahmoudzadeh,L. , , Abtahi Froushani,S. . M. , , Mahmoudzadeh,M. , and Aliyari,A. . "The effect of phlorotannin in brown algae on the function of mesenchymal stem cells and neutrophils of NMRI mice", Journal of Animal Research
(Iranian Journal of Biology), 38, 3, 2025, 199-215. doi: 10.22034/cmr.2025.8480.3302
HARVARD
Mahmoudzadeh L., Abtahi Froushani S. . M., Mahmoudzadeh M., Aliyari A. (2025). 'The effect of phlorotannin in brown algae on the function of mesenchymal stem cells and neutrophils of NMRI mice', Journal of Animal Research
(Iranian Journal of Biology), 38(3), pp. 199-215. doi: 10.22034/cmr.2025.8480.3302
CHICAGO
L. Mahmoudzadeh, S. . M. Abtahi Froushani, M. Mahmoudzadeh and A. Aliyari, "The effect of phlorotannin in brown algae on the function of mesenchymal stem cells and neutrophils of NMRI mice," Journal of Animal Research
(Iranian Journal of Biology), 38 3 (2025): 199-215, doi: 10.22034/cmr.2025.8480.3302
VANCOUVER
Mahmoudzadeh L., Abtahi Froushani S. . M., Mahmoudzadeh M., Aliyari A. The effect of phlorotannin in brown algae on the function of mesenchymal stem cells and neutrophils of NMRI mice. JAR, 2025; 38(3): 199-215. doi: 10.22034/cmr.2025.8480.3302
Journal of Animal Research
(Iranian Journal of Biology)