نوع مقاله : مقاله پژوهشی
کلیدواژهها
عنوان مقاله English
نویسندگان English
Phlorotannins, a group of polyphenol compounds found in brown seaweed, possess various beneficial properties such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancer, and neuroprotective effects. These biological activities have led to an increased demand worldwide. In this research, brown algae sourced from the Persian Gulf were utilized to extract phlorotannins. Subsequently, mesenchymal stem cells and neutrophils from NMRI mice were isolated, cultured in specific media, and exposed to varying concentrations of phlorotannin (0, 20, 60, and 100 mg/ml). The findings revealed that the survival of these cells remains unaffected with increasing compound concentrations. However, there was an enhancement in the survival and proliferation of mesenchymal stem cells. Moreover, the concentration-dependent decrease in the activity of the inflammatory enzyme nitric oxide (NO) and the secretion of the proinflammatory cytokine IL-1β were observed. Conversely, an increase in the respiratory burst of neutrophils and the secretion of immunomodulatory cytokines such as IL-10 and TGF-β was noted with higher phlorotannin concentrations. These results underscore the potent anti-inflammatory effects of these compounds, deemed safe for use due to their lack of cytotoxicity, offering a promising alternative to conventional chemicals and drugs.
کلیدواژهها English
مجله پژوهشهای جانوری (مجله زیست شناسی ایران)(علمی)